amakuru

Uburozi bwa karande bwangiza ni ikintu gikomeye gishobora gutera indwara z'umutima n'imitsi ku bantu bakuru no kutamenya neza ubwenge ku bana, kandi birashobora guteza ingaruka ndetse no ku rwego rwo hejuru rwitwa ko rufite umutekano. Muri 2019, isasu ryagize uruhare mu guhitanwa na miliyoni 5.5 bazize indwara z'umutima n'imitsi ku isi ndetse no gutakaza amanota miliyoni 765 ya IQ ku bana buri mwaka.
Kugaragara kw'isasu hafi ya hose, harimo no gusiga irangi, lisansi iyobowe, imiyoboro imwe y'amazi, ububumbyi, amavuta yo kwisiga, impumuro nziza, hamwe no gushonga, gukora bateri n'inganda, bityo ingamba zo ku rwego rw'abaturage ni ngombwa mu kurandura uburozi bwangiza.

Uburozi bw'isasu ni indwara ya kera. Dioscorides, umuganga w’umugereki akaba n’umuhanga mu bya farumasi i Roma ya kera, yanditse De
Materia Medica, umurimo w'ingenzi kuri farumasi mu myaka ibarirwa muri za mirongo, wasobanuye ibimenyetso by'uburozi bukabije bwangiza imyaka hafi 2000 ishize. Abantu bafite uburozi bwangiza cyane bafite umunaniro, kubabara umutwe, kurakara, kuribwa mu nda cyane, no kuribwa mu nda. Iyo umuvuduko w'amaraso urenze 800 μg / L, uburozi bukabije bwa gurşide bushobora gutera guhungabana, encephalopathie, n'urupfu.
Uburozi bwa chronique karande bwamenyekanye hashize ibinyejana byinshi nkimpamvu ya aterosklerozose na “sisitemu yuburozi”. Isuzuma ryakozwe, abarwayi 69 kuri 107 barwaye indwara yo mu bwoko bwa goutte “barushijeho gukomera urukuta rw'imitsi hamwe n'impinduka zidasanzwe.” Mu 1912, William Osler (William Osler)
Osler yaranditse ati: "Inzoga, isasu, na gout bigira uruhare runini mu gutera indwara ya arteriosclerose, nubwo uburyo nyabwo bwo gukora butumvikana neza". Umurongo wa sisitemu (ububiko bwiza bwubururu bwa sulfide kuruhande rwikigina) iranga uburozi bwigihe kirekire mubantu bakuru.
Mu 1924, New Jersey, Philadelphia n'Umujyi wa New York babujije kugurisha lisansi yayoboye nyuma yuko 80 ku ijana by'abakozi bakora tetraethyl isasu muri Standard Oil muri New Jersey basanze bafite uburozi bwa gurş, bamwe muri bo bakaba barapfuye. Ku ya 20 Gicurasi 1925, Hugh Cumming, umuganga mukuru w’abaganga w’Amerika, yahamagaye abahanga n’abahagarariye inganda kugira ngo bamenye niba ari byiza kongeramo tetraethyl biganisha kuri lisansi. Yandell Henderson, inzobere mu by'imiterere n’inzobere mu ntambara z’imiti, yihanangirije ko "kongeramo tetraethyl gurş bizagaragaza buhoro buhoro abaturage benshi bayobora uburozi no gukomera kwimitsi". Robert Kehoe, umuyobozi mukuru w’ubuvuzi wa Ethyl Corporation, yemeza ko inzego za leta zitagomba kubuza tetraethyl isasu mu modoka kugeza igihe bigaragaye ko ari uburozi. Kehoe yagize ati: "Ikibazo si ukumenya niba isasu riteye akaga, ahubwo ni ukumenya niba kwibumbira hamwe kw'isasu ari bibi."
Nubwo ubucukuzi bw'amabuye y'agaciro bumaze imyaka 6.000, gutunganya amasasu byiyongereye cyane mu kinyejana cya 20. Isasu nicyuma cyoroshye, kiramba gikoreshwa mukurinda lisansi gutwika vuba, kugabanya "moteri ikomanga" mumodoka, gutwara amazi yo kunywa, amabati yabagurisha, gutuma irangi rimurika kandi ryica udukoko. Kubwamahirwe, ibyinshi mubiyobora bikoreshwa muribi bikorwa birangirira mumibiri yabantu. Ku cyorezo cy’icyorezo cy’uburozi muri Amerika, abana babarirwa mu magana bajyanwaga mu bitaro buri mpeshyi bazira encephalopathie, kandi kimwe cya kane cyabo barapfa.
Muri iki gihe abantu bahura nuyobora kurwego rwo hejuru kurwego rwimiterere karemano. Mu myaka ya za 1960, umuhanga mu by'imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’imiterere y’isi mu myaka miliyari 4.5.
Patterson yasanze ubucukuzi bw'amabuye y'agaciro, gushonga no gusohora ibinyabiziga byatumye habaho isasu ryo mu kirere ryikubye inshuro 1.000 ugereranije n’urwego rw’imiterere karemano ya glacier. Patterson yasanze kandi kwibumbira hamwe kw'amasasu mu magufa y'abantu bo mu bihugu byateye imbere byikubye inshuro 1.000 ugereranije n'abantu babayeho mbere y'inganda.
Kugaragara kw'isasu byagabanutseho hejuru ya 95% kuva mu myaka ya za 70, ariko ab'iki gihe baracyafite inshuro 10-100 kurusha abantu babayeho mbere yinganda.
Usibye bike, nk'isasu mu mavuta yo mu ndege n'amasasu hamwe na batiri ya aside-acide ku binyabiziga bifite moteri, isasu ntirikoreshwa muri Amerika n'Uburayi. Abaganga benshi bemeza ko ikibazo cy’uburozi bwangiza ari ikintu cyahise. Nyamara, irangi ry'isasu mu ngo zishaje, lisansi yayoboye yashyizwe mu butaka, isasu yaturutse mu miyoboro y'amazi, hamwe n’ibyuka biva mu nganda n’inganda zitwika byose bigira uruhare mu kuyobora. Mu bihugu byinshi, isasu riva mu gushonga, kubyara bateri no kuri e-imyanda, kandi bikunze kuboneka mu marangi, ububumbyi, amavuta yo kwisiga n'impumuro nziza. Ubushakashatsi bwemeza ko uburozi bwa karande bwo mu rwego rwo hasi ari ibintu bishobora gutera indwara z'umutima n'imitsi ku bantu bakuru ndetse n'ubumuga bwo kutamenya ku bana, ndetse no mu nzego zabonwaga ko zifite umutekano cyangwa zitagira ingaruka. Iyi ngingo izavuga muri make ingaruka ziterwa n'uburozi buke bwo mu rwego rwo hasi

Kumurika, kwinjizwa hamwe n'umutwaro w'imbere
Kurya mu kanwa no guhumeka ninzira nyamukuru ziyobora. Impinja zikura vuba niterambere zirashobora gukuramo byoroshye isasu, kandi kubura fer cyangwa kubura calcium birashobora guteza imbere kwinjiza. Isasu ryigana calcium, fer, na zinc ryinjira muri selile binyuze mumiyoboro ya calcium hamwe nabatwara ibyuma nkabatwara ibyuma bisa 1 [DMT1]. Abantu bafite polymorphism genetique itera kwinjiza fer cyangwa calcium, nkibitera indwara ya hemochromatose, biyongereye kwinjiza sisitemu.
Iyo bimaze kwinjizwa, 95% by'isigarira isigaye mu mubiri w'umuntu mukuru ibikwa mu magufa; 70% by'isigarira isigaye mu mubiri w'umwana ibikwa mu magufa. Hafi ya 1% yumutwaro wose uyobora umubiri wumuntu uzenguruka mumaraso. 99% by'isasu mu maraso biri mu ngirabuzimafatizo zitukura. Amaraso yuzuye yibanze (isasu rimaze kwinjizwa hamwe na reobiliside ikomoka kumagufa) ni biomarker ikoreshwa cyane murwego rwo kwerekana. Ibintu bihindura metabolisme yamagufa, nka menopause na hyperthyroidism, birashobora kurekura isasu ryakuwe mumagufwa, bigatuma urugero rwamaraso rwiyongera.
Mu 1975, igihe isasu ryongerwaga kuri lisansi, Pat Barry yakoze ubushakashatsi bwakozwe na autopsie y’abongereza 129 kandi agereranya imitwaro yose yayoboye. Impuzandengo yumutwaro wose mumubiri wumugabo ni 165 mg, bihwanye nuburemere bwa clip. Umutwaro wumubiri wabagabo bafite uburozi bwisasu wari mg 566, wikubye inshuro eshatu gusa impuzandengo yikigereranyo cyabagabo bose. Ugereranije, impuzandengo yumutwaro wose mumubiri wumugore ni mg 104. Mu bagabo no ku bagore, ubwinshi bw’isasu mu ngingo zoroheje zari muri aorta, mu gihe ku bagabo intumbero yari myinshi muri plaque ya aterosklerotike.
Bamwe mu baturage bafite ibyago byinshi byo kwandura uburozi ugereranije n’abaturage muri rusange. Impinja hamwe n’abana bato bafite ibyago byinshi byo gufata isasu kubera imyitwarire yabo yo kutarya mu kanwa, kandi birashoboka cyane ko bayobora isasu kurusha abana bakuru ndetse nabakuze. Abana bato baba mu ngo zubatswe nabi zubatswe mbere ya 1960 bafite ibyago byo kwangiza uburozi buterwa no gufata amarangi hamwe n ivumbi ryanduye ryanduye. Abantu banywa amazi ya robine ava mu miyoboro yanduye cyangwa batuye hafi yikibuga cy’indege cyangwa ahandi hantu handuye na sisitemu na bo bafite ibyago byinshi byo kwandura uburozi bwo mu rwego rwo hasi. Muri Reta zunzubumwe zunzubumwe zunzubumwe zunzubumwe zunzubumwe zunzubumwe zunzubumwe zunzubumwe zunzubumwe zunzubumwe zunzubumwe zamerika Abakozi bakora mu gushonga, gutunganya batiri no mu nganda zubaka, kimwe n’abakoresha imbunda cyangwa bafite ibice by’amasasu mu mibiri yabo, na bo bafite ibyago byinshi byo kwangiza uburozi.
Isasu ni imiti yambere yuburozi yapimwe mubushakashatsi bwigihugu bwita ku buzima n’imirire (NHANES). Mu ntangiriro ya fonctionnement ya lisansi iyobowe, urugero rw'amaraso yagabanutse kuva kuri 150 μg / L mu 1976 kugeza 90 muri 1980
μg / L, umubare w'ikigereranyo. Urwego rwo kuyobora amaraso rushobora kuba rwangiza rwaragabanutse inshuro nyinshi. Mu mwaka wa 2012, Ikigo gishinzwe kurwanya no gukumira indwara (CDC) cyatangaje ko urwego rw’umutekano muke mu maraso y’abana rutaramenyekana. CDC yagabanije igipimo cy’amaraso arenze urugero ku bana - akenshi ikoreshwa mu kwerekana ko hagomba gufatwa ingamba zo kugabanya kwandura indwara - kuva 100 μg / L kugeza kuri 50 μg / L muri 2012, no kuri 35 μg / L mu 2021. Kugabanuka kw'ibipimo by’amaraso arenze urugero byagize ingaruka ku cyemezo cyacu cy'uko iyi mpapuro izakoresha μg / L nk'urwego rwo gupima uburozi bukoreshwa cyane.

Urupfu, uburwayi n'ubumuga
Paul Mushak na Annemarie F. Crocetti, bombi bagize bagize Ikigo cy’igihugu gishinzwe ubuziranenge bw’ikirere cyashyizweho na Perezida Jimmy Carter, muri raporo yagejeje kuri Kongere mu mwaka wa 1988. Uburozi buke bw’isasu ni ibintu bishobora gutera kubyara hakiri kare, kimwe no kutamenya ubwenge no kutita ku ndwara ya hyperactivite (ADHD), kongera umuvuduko w’amaraso no kugabanya umuvuduko w’umutima ku bana. Ku bantu bakuze, uburozi buke bwa sisitemu ni ibintu bishobora gutera impyiko zidakira, hypertension n'indwara z'umutima

Gukura na neurodevelopment
Iyo intungamubiri za gurş zikunze kugaragara ku bagore batwite, kwandura indwara ni ibintu bishobora gutera kubyara imburagihe. Mu byifuzo by’amavuko by’Abanyakanada, kwiyongera kwa 10 μg / L kwiyongera kw'amaraso y’ababyeyi byatewe no kwiyongera 70% by’ibyago byo kubyara bidatinze. Ku bagore batwite bafite vitamine D ya serumu iri munsi ya 50 mmol / L naho urugero rw'amaraso rwiyongereyeho 10 μg / L, ibyago byo kubyara bidatinze byiyongereye bikubye inshuro eshatu.
Mubushakashatsi bwibanze bwibanze bwabana bafite ibimenyetso byubuvuzi bwuburozi bwa sisitemu, Urushinge nibindi. basanze abana bafite urwego rwo hejuru bayobora bafite amahirwe menshi yo kwandura defisite ya neuropsychologue kurusha abana bafite urwego ruto rwo kuyobora, Kandi bakunze guhabwa amanota nkabakene nabarimu mubice nko kurangaza, ubumenyi bwumuteguro, kudashyira mu gaciro nibindi biranga imyitwarire. Nyuma yimyaka icumi, abana bari mumatsinda bafite urwego runini rwa dentin bayoboye inshuro 5.8 bafite ikibazo cyo kutagira dyslexia ndetse ninshuro 7.4 bakareka ishuri kurusha abana bari mumatsinda bafite urwego rwo hasi.
Ikigereranyo cyo kugabanuka kwubwenge kwiyongera mubyiciro byayoboye byari byinshi mubana bafite urwego ruto rwo kuyobora. Mu isesengura ryakozwe ku bantu barindwi bashobora guhura, kwiyongera k'urwego rw'amaraso kuva kuri 10 μg / L kugera kuri 300 μg / L byajyanye no kugabanuka kw'amanota 9 mu IQ y'abana, ariko igabanuka ryinshi (kugabanuka kw'amanota 6) ryabaye igihe urwego rw'amaraso rwiyongera bwa mbere 100 μg / L. Dose-gusubiza umurongo wasaga no kugabanuka kwubwenge bujyanye nurwego rwapimwe kurwego rwamagufwa na plasma.

Kugaragara kw'isasu ni ibintu bishobora guteza ibibazo by'imyitwarire nka ADHD. Mu bushakashatsi bwakozwe na Leta zunze ubumwe z’Amerika ku bana bafite hagati y’imyaka 8 na 15, abana bafite urugero rw’amaraso arenze 13 μg / L bakubye kabiri ADHD kurusha abafite urugero rw’amaraso muri quintile yo hasi. Muri aba bana, abagera kuri 1 kuri 5 ba ADHD barashobora kwitirirwa kuyobora.

Kugaragara kw'abana bato ni ibintu bishobora guteza imyitwarire idahwitse, harimo imyitwarire ijyanye n'imyitwarire idahwitse, ubugizi bwa nabi, n'imyitwarire y'ubugizi bwa nabi. Mu isesengura ryakozwe n’ubushakashatsi 16, umuvuduko ukabije w’amaraso wajyanye n’imyitwarire idahwitse ku bana. Mu bushakashatsi bubiri bwateganijwe bwa cohort, urugero rwinshi rwamaraso cyangwa urugero rwa dentin mu bwana byajyanye nigipimo kinini cy’ubugizi bwa nabi no gufatwa ukiri muto.
Indwara ya sisitemu nyinshi mu bwana yajyanye no kugabanuka kwubwonko (birashoboka bitewe nubunini bwa neuron hamwe nishami rya dendrite), kandi ubwonko bwagabanutse bwakomeje kuba mukuru. Mu bushakashatsi bwarimo abantu bakuru, amaraso menshi cyangwa amagufwa yo mu magufa birashoboka ko bifitanye isano no kugabanuka kwubwenge bwihuse, cyane cyane kubatwaye APOE4 allele. Indwara yo mu bwana ikiri muto ishobora kuba intandaro yo kwandura indwara ya Alzheimer itinze, ariko ibimenyetso ntibisobanutse.

Nephropathie
Kurwara isonga ni ibintu bishobora gutera indwara zimpyiko zidakira. Ingaruka za nephrotoxic ya gurş zigaragarira mumibiri yimibiri ya nucleaire yimitsi yimpyiko yegeranye, tubule interstitial fibrosis hamwe no kunanirwa kwimpyiko zidakira. Mu bitabiriye ubushakashatsi bwa NHANES hagati ya 1999 na 2006, abantu bakuze bafite umuvuduko ukabije w'amaraso uri hejuru ya 24 μg / L ni bo 56% bafite amahirwe yo kugabanuka kwa filture yo ku isi (<60 mL / [min · 1.73 m2]) kurusha abafite umuvuduko ukabije w'amaraso uri munsi ya 11 μg / L. Mu bushakashatsi bwakorewe hamwe, abantu bafite umuvuduko ukabije w'amaraso uri hejuru ya 33 μg / L bafite ibyago 49% byo kwandura indwara zimpyiko zidakira kurusha abafite umuvuduko muke w'amaraso.

Indwara z'umutima
Impinduka ziterwa na selile ziranga umuvuduko ukabije wamaraso hamwe na aterosklerose. Mu bushakashatsi bwakorewe muri laboratoire, urugero ruto rwinshi rw'isasu rwiyongera rwongera imbaraga za okiside, kugabanya urugero rwa oxyde nitric oxyde, kandi bigatera vasoconstriction ukoresheje protein kinase C, bigatuma hypertension ikomeza. Kurwanya isasu bidakora aside nitide, byongera hydrogène peroxide, bikabuza gusana endoteliyale, bikangiza angiogenez, bigatera trombose, kandi biganisha kuri aterosklerose (Ishusho 2).
Ubushakashatsi bwakozwe na vitro bwerekanye ko ingirabuzimafatizo ya endoteliyale yatewe mu bidukikije hamwe na 0.14 kugeza 8.2 μg / L mu gihe cy'amasaha 72 byangiza ingirabuzimafatizo (amarira mato cyangwa gutobora byerekanwa na scanning microscopi electron). Ubu bushakashatsi butanga ibimenyetso bya ultrastructures byerekana ko isasu cyangwa isasu byongeye kwinjizwa mu maraso bivuye ku magufa bishobora gutera imikorere mibi ya endoteliyale, akaba ari yo mpinduka ya mbere igaragara mu mateka karemano y’indwara ya aterosklerotike. Mu isesengura ry’ibice byerekana icyitegererezo cy’abantu bakuze bafite impuzandengo y’amaraso ya 27 μg / L kandi nta mateka y’indwara zifata umutima, urugero rw’amaraso rwiyongereyeho 10%
Kuri μg, ikigereranyo cyo gutandukanya imiyoboro ikabije ya aroni (ni ukuvuga amanota ya Agatston> 400 hamwe n'amanota 0 [0 yerekana ko nta calcisation] n'amanota menshi yerekana intera nini yo kubara) yari 1.24 (95% intera y'icyizere 1.01 kugeza 1.53).
Kurwara isasu ni ikintu gikomeye gishobora guhitanwa n'indwara z'umutima. Hagati ya 1988 na 1994, Abanyamerika 14.000 bakuze bitabiriye ubushakashatsi bwa NHANES hanyuma bakurikiranwa imyaka 19, muri bo 4.422 barapfa. Umuntu umwe kuri batanu apfa azize indwara z'umutima. Nyuma yo guhinduka kubindi bintu bishobora guteza ibyago, kongera umuvuduko wamaraso uva kumurongo wa 10 ku ijana ukagera kuri 90 ku ijana byajyanye no gukuba kabiri ibyago byo guhitanwa nindwara z'umutima. Ibyago byindwara zifata umutima nimiyoboro yindwara yumutima byiyongera cyane mugihe urugero rwa sisitemu ruri munsi ya 50 μg / L, nta mbibi zisobanutse (Ishusho 3B na 3C). Abashakashatsi bemeza ko kimwe cya kane cya miliyoni z'impfu z'umutima n'imitsi itaragera buri mwaka biterwa n'uburozi budakira bwo mu rwego rwo hasi. Muri bo, 185.000 bapfuye bazize indwara z'umutima.
Kurwara gurş bishobora kuba imwe mumpamvu zitera impfu zindwara z'umutima zabanje kwiyongera hanyuma zikagwa mu kinyejana gishize. Muri Amerika, umubare w'abahitanwa n'indwara z'umutima wa koronari wazamutse cyane mu gice cya mbere cy'ikinyejana cya 20, ugera ku 1968, hanyuma ugabanuka gahoro gahoro. Ubu iri 70 ku ijana munsi yimpinga ya 1968. Guhura na lisansi yayoboye byajyanye no kugabanuka kw'impfu ziterwa n'indwara z'umutima (Ishusho 4). Mu bitabiriye ubushakashatsi bwa NHANES, bwakurikiranwe mu gihe kigera ku myaka umunani hagati ya 1988-1994 na 1999-2004, 25% by'igabanuka rusange ry’indwara z'umutima zatewe no kugabanuka kw'amaraso.

Mu myaka ya mbere yo gukuraho lisansi yayoboye, umubare w’umuvuduko ukabije w’amaraso muri Amerika wagabanutse cyane. Hagati ya 1976 na 1980, 32 ku ijana by'abantu bakuru b'Abanyamerika bari bafite umuvuduko ukabije w'amaraso. Muri 1988-1992, igipimo cyari 20% gusa. Ibintu bisanzwe (kunywa itabi, imiti yumuvuduko wamaraso, umubyibuho ukabije, ndetse nubunini bunini bwa cuff bukoreshwa mugupima umuvuduko wamaraso kubantu bafite umubyibuho ukabije) ntibisobanura kugabanuka k'umuvuduko wamaraso. Nyamara, urwego rwo hagati rwamaraso rwagati muri Reta zunzubumwe zamerika rwamanutse ruva kuri 130 μg / L mu 1976 rugera kuri 30 μg / L mu 1994, byerekana ko kugabanuka kw’isasu ari imwe mu mpamvu zituma umuvuduko wamaraso ugabanuka. Mu bushakashatsi bukomeye bw’umuryango, bwarimo itsinda ry’Abanyamerika ry’Abahinde, urugero rw’amaraso yagabanutseho ≥9 μg / L naho umuvuduko w’amaraso wa systolique wagabanutse ku kigereranyo cya 7.1 mm Hg (agaciro kahinduwe).
Ibibazo byinshi bikomeje kuba ibisubizo ku ngaruka ziterwa no kurwara indwara zifata umutima. Igihe cyo guhura gisabwa gutera hypertension cyangwa indwara z'umutima-damura ntikirasobanuka neza, ariko guhura kwigihe kirekire kumasemburo yapimwe mumagufwa bigaragara ko afite imbaraga zo guhanura kuruta guhura nigihe gito gipimwa mumaraso. Ariko, kugabanya isasu bigaragara ko bigabanya umuvuduko wamaraso hamwe nimpanuka zurupfu rwindwara zifata umutima nimiyoboro yumwaka 1 kugeza 2. Umwaka umwe nyuma yo kubuza lisansi yayobowe mumarushanwa ya NASCAR, abaturage hafi yumuhanda bari bafite umubare muto cyane wimpfu zindwara z'umutima ugereranije nabaturage benshi. Hanyuma, harakenewe kwiga ingaruka z'umutima-mitsi wigihe kirekire kubantu bahuye nurwego rwo munsi ya 10 μg / L.
Kugabanuka guhura nindi miti yubumara nabyo byagize uruhare mu kugabanuka kwindwara z'umutima. Guhagarika lisansi yayoboye kuva 1980 kugeza 2000 yagabanije ibintu bito mubice 51 byumujyi, bigatuma ubuzima bwiyongera 15%. Abantu bake ni bo banywa itabi. Mu 1970, abagera kuri 37 ku ijana by'abantu bakuru b'Abanyamerika banywa itabi; Kugeza mu 1990, Abanyamerika 25% bonyine ni bo banywa itabi. Abanywa itabi bafite umuvuduko mwinshi w'amaraso kurusha abatarinywa. Biragoye gukuraho ingaruka zamateka n’ubu ziterwa n’umwanda uhumanya ikirere, umwotsi w’itabi hamwe n’indwara ku mutima.
Indwara z'umutima ni zo ziza ku isonga mu guhitana abantu ku isi. Ubushakashatsi burenga icumi bwerekanye ko kwandura indwara ari ikintu gikomeye kandi akenshi cyirengagizwa ku mpfu ziterwa n'indwara z'umutima. Mu isesengura ryakozwe na meta, Chowdhury n'abandi basanze ko umuvuduko ukabije w'amaraso ari ibintu by'ingenzi bitera indwara z'umutima. Mu bushakashatsi umunani buteganijwe (hamwe n’abitabiriye 91,779 bose hamwe), abantu bafite intungamubiri z’amaraso muri quintile nyinshi bari bafite ibyago 85% by’indwara ziterwa na infiyite ya myocardial idapfa, kubagwa bypass, cyangwa gupfa bazize indwara z'umutima zifata umutima kurusha izo muri quintile yo hasi. Muri 2013, Ikigo gishinzwe kurengera ibidukikije (EPA)
Ikigo gishinzwe kurengera cyanzuye ko kwandura indwara ari ibintu bishobora gutera indwara z'umutima; Nyuma yimyaka icumi, Ishyirahamwe ryumutima wabanyamerika ryemeje uwo mwanzuro.