amakuru

Interferon ni ikimenyetso cyasohowe na virusi mu bakomoka ku mubiri kugira ngo bakore sisitemu y’umubiri, kandi ni umurongo wo kwirinda virusi.Ubwoko bwa I interferons (nka alfa na beta) byakozwe mumyaka mirongo nkibiyobyabwenge bya virusi.Nyamara, ubwoko bwa I interferon reseptors bugaragarira mubice byinshi, bityo rero imiyoborere yubwoko bwa I interferon iroroshye kuganisha ku gukabya gukingira umubiri kwumubiri, bikavamo urukurikirane rwingaruka.Itandukaniro nuko ubwoko bwa III interferon (λ) bwakirwa bugaragarira gusa mubice bya epiteliyale hamwe na selile zimwe na zimwe z'umubiri, nk'ibihaha, inzira z'ubuhumekero, amara, n'umwijima, aho igitabo cyitwa coronavirus gikora, bityo interferon λ ikagira ingaruka nke.PEG-λ ihindurwa na polyethylene glycol hashingiwe kuri interferon naturel, kandi igihe cyo kuzenguruka mu maraso ni kirekire cyane ugereranije na interferon naturel.Ubushakashatsi bwinshi bwerekanye ko PEG-λ ifite ibikorwa byinshi bya virusi ya virusi

Nko muri Mata 2020, abahanga bo mu kigo cy’igihugu gishinzwe kanseri (NCI) muri Amerika, Ishuri Rikuru rya King London mu Bwongereza ndetse n’ibindi bigo by’ubushakashatsi basohoye ibisobanuro muri J Exp Med basaba ko ubushakashatsi bw’amavuriro bwifashisha interferon λ mu kuvura Covid-19.Raymond T. Chung, umuyobozi w'ikigo cya Hepatobiliary mu bitaro bikuru bya Massachusetts muri Amerika, na we yatangaje muri Gicurasi ko hazakorwa urubanza rw’amavuriro rwatangijwe n’iperereza kugira ngo harebwe niba PEG-λ irwanya Covid-19.

Ibizamini bibiri byo mu cyiciro cya 2 byerekanye ko PEG-λ ishobora kugabanya cyane virusi ya virusi ku barwayi bafite COVID-19 [5,6].Ku ya 9 Gashyantare 2023, Ikinyamakuru cy’ubuvuzi cya New England (NEJM) cyasohoye ibyavuye mu igeragezwa ry’icyiciro cya 3 cy’imihindagurikire y’ikirere cyiswe TOGETHER, kiyobowe n’intiti zo muri Berezile na Kanada, cyanasuzumye ingaruka zo kuvura PEG-λ ku barwayi ba COVID-19 [7].

Abarwayi bagaragaza ibimenyetso bikaze bya Covid-19 kandi bakerekana mugihe cyiminsi 7 ibimenyetso bitangiye bakiriye PEG-λ (inshinge imwe yo munsi yubutaka, 180 μg) cyangwa umwanya wa (inshinge imwe cyangwa umunwa).Igisubizo cyibanze cyibanze ni ibitaro (cyangwa koherezwa mubitaro bya kaminuza) cyangwa ishami ryihutirwa gusura Covid-19 mugihe cyiminsi 28 uhereye igihe utabishaka (kwitegereza> amasaha 6).

Igitabo coronavirus cyahindutse kuva icyorezo cyatangira.Niyo mpamvu, ni ngombwa cyane cyane kureba niba PEG-λ igira ingaruka zo gukiza kubintu bitandukanye bya coronavirus.Iri tsinda ryakoze isesengura ry’itsinda ry’imiterere itandukanye ya virusi yanduye abarwayi muri iki kigeragezo, harimo Omicron, Delta, Alpha, na Gamma.Ibisubizo byagaragaje ko PEG-λ yagize akamaro mu barwayi bose banduye izo variants, kandi ikaba nziza cyane ku barwayi banduye Omicron.

Ku bijyanye n'umutwaro wa virusi, PEG-λ yagize ingaruka zikomeye zo kuvura abarwayi bafite virusi ya virusi yibanze, mu gihe nta ngaruka zikomeye zo kuvura zagaragaye ku barwayi bafite virusi nkeya ya virusi.Iyi efficacy isa hafi na Paxlovid ya Pfizer (Nematovir / Ritonavir).

Twabibutsa ko Paxlovid itangwa mukanwa hamwe n'ibinini 3 kumunsi kabiri muminsi 5.Ku rundi ruhande, PEG-λ isaba gusa inshinge imwe yo mu nsi yo munsi kugirango igere ku bikorwa bimwe na Paxlovid, bityo ikaba ifite kubahiriza neza.Usibye kubahiriza, PEG-λ ifite izindi nyungu kurenza Paxlovid.Ubushakashatsi bwerekanye ko Paxlovid yoroshye gutera imikoranire yibiyobyabwenge kandi bigira ingaruka kuri metabolisme yibindi biyobyabwenge.Abantu bafite ikibazo kinini cya Covid-19, nk'abarwayi bageze mu zabukuru n'abarwayi bafite indwara zidakira, bakunda gufata ibiyobyabwenge igihe kirekire, bityo ibyago bya Paxlovid muri aya matsinda bikaba byinshi cyane ugereranije na PEG-λ.

Byongeye kandi, Paxlovid ni inhibitor yibasira protease za virusi.Niba poroteyine ya virusi ihindagurika, imiti irashobora kutagira icyo ikora.PEG-λ yongera imbaraga mu kurandura virusi ikora ubudahangarwa bw'umubiri, kandi ntabwo yibasira imiterere ya virusi.Kubwibyo, niyo virusi yaba ihinduka mugihe kizaza, PEG-λ biteganijwe ko izakomeza gukora neza.

Icyakora, FDA yavuze ko itazemera ko hakoreshwa byihutirwa PEG-λ, bikabababaza abahanga bagize uruhare muri ubwo bushakashatsi.Eiger avuga ko ibyo bishobora kuba biterwa n'ubushakashatsi butarimo ikigo cy’ubuvuzi cyo muri Amerika, kandi kubera ko urubanza rwatangijwe kandi rwakozwe n’abashakashatsi, atari ibigo by’ibiyobyabwenge.Nkigisubizo, PEG-λ izakenera gushora amafaranga atari make nigihe kinini mbere yuko itangizwa muri Amerika.

Nkumuti mugari wa virusi ya virusi, PEG-λ ntabwo yibasira gusa igitabo cyitwa coronavirus, irashobora kandi kongera umubiri kwanduza izindi virusi.PEG-λ igira ingaruka kuri virusi yibicurane, virusi yubuhumekero nizindi coronavirus.Ubushakashatsi bumwe bwerekanye kandi ko drugs imiti ya interferon, iyo ikoreshejwe hakiri kare, ishobora guhagarika virusi kwanduza umubiri.Eleanor Fish, inzobere mu gukingira indwara muri kaminuza ya Toronto muri Kanada utagize uruhare mu bushakashatsi bwa TOGETHER, yagize ati: “Ikoreshwa ryinshi muri ubu bwoko bwa interferon ryaba ari ubuhanuzi, cyane cyane mu rwego rwo kurinda abantu bafite ibyago byinshi kwandura mu gihe cy’indwara.”